Noninvasive 3D-PAULM imaging technology reveals brain-wide glymphatic system dynamics
By
Junjie Yao
Summary
This article reports on a new hybrid imaging technology called 3D-PAULM (three-dimensional photoacoustic tomography and ultrasound localization microscopy) that enables noninvasive whole-brain imaging of glymphatic system dynamics. The glymphatic system is responsible for clearing metabolic waste from the central nervous system via cerebrospinal fluid circulation, but its mechanisms have been poorly understood due to lack of deep brain imaging technologies. The new approach is enhanced by a photoacoustic dye with strong optical absorption in the second near-infrared window (NIR-II), allowing researchers to visualize brain-wide glymphatic dynamics noninvasively.
Source
Twitter / XNoninvasive 3D-PAULM imaging technology reveals brain-wide glymphatic system dynamicsscience.orgKey quotes
· 3 pulledCerebrospinal fluid circulation through the glymphatic system plays a crucial role in removing metabolic waste from the central nervous system.
However, the mechanism underlying the brain-wide glymphatic dynamics is not yet fully understood, in part due to the lack of glymphatic imaging technologies on deep brains.
Here, we report a hybrid imaging technology that integrates three-dimensional photoacoustic tomography and ultrasound localization microscopy (3D-PAULM), enhanced by a photoacoustic dye with strong optical absorption in the second near-infrared window (NIR-II).
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