ACTIV-6 Trial: Metformin Treatment During Acute COVID-19 May Reduce Long-Term Symptoms at 6 Months
By
Bramante, Carolyn T, Stewart, Thomas G, Boulware, David R, McCarthy, Matthew W, Gao, Yue, Rothman, Russell L, Mourad, Ahmad, Thicklin, Florence, Cohen, Jonathan B, Garcia del Sol, Idania T, Shah, Nirav S, Mehta, Manisha, Quintero Cardona, Orlando, Scott, Jake, Ginde, Adit A, Castro, Mario, Jayaweera, Dushyantha, Sulkowski, Mark, Gentile, Nina, McTigue, Kathleen, Felker, G Michael, Collins, Sean, Dunsmore, Sarah E, Adam, Stacey J, Lindsell, Christopher J, Hernandez, Adrian F, Naggie, Susanna, ,
Summary
This article reports on the ACTIV-6 randomized clinical trial investigating whether metformin, when used to treat acute COVID-19, reduces the presence of symptoms 6 months after infection. The study found that treating acute COVID-19 with 14 days of metformin has a 63–98% probability of cutting the risk in half of having any symptoms, more severe symptoms, or a composite outcome at 6 months post-infection.
Source
bskyACTIV-6 Trial: Metformin Treatment During Acute COVID-19 May Reduce Long-Term Symptoms at 6 Monthsacademic.oup.comKey quotes
· 1 pulledTreating acute COVID-19 with 14 days of metformin has a 63–98% probability of cutting the risk in half of having any symptoms, more severe symptoms, or a composite outcome at 6 months post-infection.
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