All Topics
All Topics
Technology
Technology
AI
AI
Business
Business
Entertainment
Entertainment
News
News
Programming
Programming
Science
Science
Design
Design
Environment
Environment
Finance
Finance
Crypto
Crypto
Politics
Politics
Sports
Sports
Education
Education
Gaming
Gaming
Art
Art
Music
Music
Health
Health
Security
Security
Books
Books
Food
Food
Travel
Travel
Personal
Personal
Bluesky
Twitter

Loss of TDP-43 in microglia linked to neurological disease development

Original story from the University of Lausanne (Switzerland). Researchers uncovered a new role for the TDP-43 protein in controlling the function of microglia, the immune cells of the brain. Their…

Read the full article
Beatrice Bowlby3d agoen

You might also wanna read

Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice - Nature Aging

A study in Nature Aging identifies a region of the ALS-linked protein TDP-43 and shows that a brain-penetrant small molecule targeting this

go.nature.com·8d ago

Microglia as central coordinators of brain-body neuroimmune communication beyond phagocytosis

Bidirectional crosstalk between the immune and nervous systems, via ‘neuroimmune circuits’, regulates homeostatic and inflammatory responses

cell.com·27d ago

Brain's immune cells put the brakes on out-of-control circuits in mouse model of Alzheimer's disease

Researchers at Trinity College Dublin have discovered that microglia—the main immune cells of the brain—play a critical role in maintaining

Meridia·1d ago

Brain’s immune cells play key role in maintaining stability of neuronal networks in Alzheimer's disease

Researchers at Trinity College Dublin have discovered that microglia – the main immune cells of the brain – play a critical role in maintain

news-medical.net·1d ago

TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration

Dominant mutations in progranulin (GRN) gene cause frontotemporal lobar degeneration (FTLD-GRN), whereas homozygous GRN mutations lead to ne

jci.org

Exploring Intracellular Communication to Understand Neurodegeneration

Investigators have uncovered a new communication pathway between mitochondria and RNA granules that may improve the understanding of how the

news.northwestern.edu·1mo ago

Comments

Sign in to join the conversation.

No comments yet. Be the first.