Study Finds Children with MIS-C Face Significantly Higher Long-Term Health Risks Years After COVID-19

Mehrotra-Varma, Shiv, Nguyen, Hien Quang, Henry, Sonya, Collins, Jessilin, Mehrotra-Varma, Jai, Changela, Sagar, Duong, Tim Q.

20d ago· 26 min readenNews

science health

Summary

A study of 173 children with MIS-C (multisystem inflammatory syndrome in children) compared to 14,190 without MIS-C, tracked up to 4.5 years after COVID-19 infection. Results show MIS-C is associated with significantly higher long-term risks across multiple organ systems: cardiovascular disorders (13.88x risk), hypertension (8.86x), gastrointestinal disorders (9.48x), respiratory disorders (3.46x), and neurological disorders (2.02x). Preexisting conditions like hypertension and diabetes further elevated risks. The study challenges earlier reports that MIS-C was transient, concluding that structured long-term multidisciplinary follow-up care is warranted.

Source

bskyStudy Finds Children with MIS-C Face Significantly Higher Long-Term Health Risks Years After COVID-19publications.aap.org

Key quotes

· 5 pulled

Compared with patients without, patients with MIS-C showed markedly higher risk of cardiovascular disorders (adjusted hazard ratio [aHR] = 13.88 [4.69–41.07], P < .001)

MIS-C is associated with broad multisystem morbidity persisting years after acute COVID-19, challenging earlier reports of transient illness.

Structured long-term follow-up, including routine blood pressure monitoring, neurological and mental-health screening, and cardiovascular and renal surveillance, with coordinated multidisciplinary care is warranted.

Preexisting diabetes (1.73% of patients with MIS-C) was associated with a 49-fold increased risk of CKD.

Kaplan-Meier analysis showed higher persistent risk in the MIS-C group across all outcomes, ranging from 6.8% for CKD to 35.2% for respiratory disorders.

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OBJECTIVES. The risk of persistent multisystem dysfunction following multisystem inflammatory syndrome in children (MIS-C), a severe postviral complication of COVID-19, remains unknown.METHODS. We investigated long-term outcomes in patients younger than 2

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