[Linkpost] “How I think about catastrophic biological risk (part I)” by ASB

This is a link post. Our mission is to protect humanity against biological catastrophes, including those that could lead to human extinction or cause similarly bad outcomes. This series of posts outlines how I think about these most extreme types of risks. My goal here is to share my worldview in a straightforward and compressed form rather than trying to persuade a skeptical audience, although I do share some of my reasoning. Part I describes my views on the sources of risk and what that implies for how to prioritize response to a biological catastrophe. Part II, describes sources of risk and what that implies for prevention efforts. TLDR: We can solve the vast majority of existential biological risk by ubiquitously deploying simple and cheap countermeasures like PPE, air filters, UVC, etc. My takes are: >99% of existential risk is from engineered threats, <1% natural threats >95% of existential risk is targeting humans, <5% targeting agriculture or the environment The space of possible human-targeted attacks is basically infinite, so predicting cures or vaccines in advance is hopeless… …but the space of physical pathways into a human body is both finite and small, which means, if this is true… …we [...] --- Outline: (02:13) Direct vs. indirect existential risk (03:26) Natural vs. engineered (04:36) Targeting human bodies vs. agriculture vs environment (08:09) The space of human-targeted biological threats is vast and unpredictable (10:15) Can we affordably block ~all human-targeted biological risk? (and thus ~all catastrophic bio risk?) (13:47) A surprisingly hopeful conclusion The original text contained 12 footnotes which were omitted from this narration. --- First published: May 16th, 2026 Source: Linkpost URL: --- Narrated by TYPE III AUDIO .