Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm
Lenacapavir (LEN) is the first human immunodeficiency virus type 1 (HIV-1) capsid inhibitor approved for clinical use in humans. It inhibits multiple steps of the viral life cycle; however, the…
Read the full articleYou might also wanna read
HIV-1 signalling remodels nuclear pores to licence infection - Nature
🧪
POPSICLE: A Benchmark Suite for Machine Learning in Cryo-Electron Tomography
Cryo-electron tomography (cryoET) has emerged as a powerful tool in structural and cellular biology by enabling direct visualization of macr
AI-designed protein nanocages self-assemble into virus-like structures for drug delivery
An international collaboration has developed AI-designed protein structures that self-assemble into virus-like nanocages using quasisymmetry

Genome-wide CRISPR screens identify host factors that promote and restrict HIV infection in primary CD4+ T cells
Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells systematically identify host proviral and antiviral factors

RNA sequence changes predict cellular activity through conformational ensemble thermodynamics
The RNA sequence of HIV-1 TAR was systematically altered to change its propensity to adopt a functional secondary structure in the ensemble,

Genome-wide CRISPR screens identify host factors that promote and restrict HIV infection in primary CD4+ T cells
Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells systematically identify host proviral and antiviral factors

Comments
Sign in to join the conversation.
No comments yet. Be the first.