Impacts of DNA methylation on H2A.Z deposition and nucleosome stability
The histone variant H2A.Z and DNA methylation are enriched at mutually exclusive genomic segments, though its mechanistic bases remain unclear. Here, we examine DNA methylation’s influence on the…
Read the full articleYou might also wanna read
Nature research paper: Replication-stress-induced chromatin loops protect fork stability
Nature research paper: Replication-stress-induced chromatin loops protect fork stability
Recognition and silencing of a new transposable element
New study in S. pombe shows a newly invading TE, tj1, gets silenced by RNAi and heterochromatin, revealing cellular threat recognition mecha
Epigenetic clocks as quantitative readouts of epigenetic drift
Epigenetic clocks as quantitative readouts of epigenetic drift
Study Challenges Decades-Old View That DNA Is Locked Away When Wrapped Around Nucleosomes
A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and ot
gladstone.org·2mo agoDNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes
CRTC2 shifts roles from transcription to DNA repair, enhancing NHEJ and suppressing antitumor immunity. Study reveals its critical involveme
Identification of a mechanism-based binding mode for a histone deacetylase 6 inhibitor
Breaking: BAS-2, a new HDAC6 inhibitor without typical zinc-binding group was identified! Using X-ray, mutagenesis, SARs & modeling, its uni

Comments
Sign in to join the conversation.
No comments yet. Be the first.