All Topics
All Topics
Technology
Technology
AI
AI
Business
Business
Entertainment
Entertainment
News
News
Programming
Programming
Science
Science
Design
Design
Environment
Environment
Finance
Finance
Crypto
Crypto
Politics
Politics
Sports
Sports
Education
Education
Gaming
Gaming
Art
Art
Music
Music
Health
Health
Security
Security
Books
Books
Food
Food
Travel
Travel
Personal
Personal
Bluesky
Twitter

uPAR-targeted CAR T cells show broad vulnerability in solid tumors with TP53/RAS mutations in preclinical models

Synergizing with senescence-inducing therapies, uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical…

Read the full article

You might also wanna read

Antibody-ligand motif optimization enables multitarget switchable CAR-T therapy against solid tumors

Wang et al. designed a sCAR-T to overcome solid tumor heterogeneity and the tumor microenvironment. The fusion of scFv with ligands enables

cell.com·13d ago

Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10641-1 Integrated multi-omic profiling of glioblastoma reveals GPNMB as a sh

Nature Communications·9d ago

AI-guided discovery identifies GPNMB as promising CAR T cell target for multiple cancers

An AI-guided framework integrating high-resolution cellular atlases, public knowledge databases, and large language models enables a modular

cell.com·14d ago

A Multicenter, Open-label, Non-randomized, Single-arm Phase 1/2 Study of Autologous Nano CD5-CAR T Cells for the Treatment of Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma

Conditions : T-Cell Acute Lymphoblastic Leukemia; T-Lymphoblastic Lymphoma; Relapsed/Refractory Hematologic Malignancies Interventions : Bio

clinicaltrials.gov·9d ago

An Early Clinical Study to Evaluate the Safety and Efficacy of CLDN18.2 CAR T Cell Injection in Subjects With CLDN18.2-Positive Advanced Malignant Solid Tumors

Conditions : CLDN18.2 Positive Solid Tumors Interventions : Biological: SUV2208A cell injection; Biological: SUV2208A; Biological: SUV2208A

clinicaltrials.gov·8d ago

Científicos financiados por los Institutos Nacionales de la Salud descubren pistas sobre las lesiones precancerosas y la biología tumoral

En nuevos estudios publicados por la Red del Atlas de Tumores Humanos (HTAN) del Instituto Nacional del Cáncer (NCI), se explora la función

NCI·1y ago

Comments

Sign in to join the conversation.

No comments yet. Be the first.