Study identifies STING ER-exit motif and COPII cargo recognition mechanism

Summary

This study identifies the EEΦxΦ motif (339EEVTV343 in human STING) as the ER-exit motif recognized by SEC24C, a COPII vesicle cargo-binding protein. Using AlphaFold3, the researchers present a predicted structure of SEC24C binding to a STING dimer, revealing this motif in a previously unresolved region. Mutations in this motif or the SEC24C cargo-binding site disrupt STING trafficking and signaling, demonstrating how STING achieves controlled rather than constitutive ER exit and how COPII cargo recognition can modulate STING signaling.

Source

B

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