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HNF4α controls growth, identity, and KRAS inhibitor response in invasive mucinous adenocarcinoma of the lung

Cellular plasticity is a hallmark of cancer, enabling tumor cells to alter identity and evade therapeutic pressure. In invasive mucinous adenocarcinoma of the lung (IMA), NK2 homeobox 1 (NKX2-1) loss…

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Study reveals how opposing oncogenic and tumor-suppressive forces converge to drive benign-to-malignant transition in pancreatic cancer

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Restraint of melanoma progression by cells in the local skin environment

Keratinocytes, the dominant cell type in the melanoma microenvironment during tumor initiation, exhibit diverse effects on melanoma progress

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