Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers

Nature research paper: Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Nature research paper: Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Role of a Mitochondrial Receptor in Blood Sugar Regulation

Conditions : Heathly Volunteers Interventions : Drug: XBD173; Drug: Placebo Sponsors : Imperial College London Recruiting

<![CDATA[Targeting Aldosterone at Its Source: The Arrival of Baxdrostat for Resistant Hypertension]]>

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation

Fluoxetine disrupts cholesterol metabolism in endothelial cells via SREBP2 activation

Antibody-ligand motif optimization enables multitarget switchable CAR-T therapy against solid tumors

Wang et al. designed a sCAR-T to overcome solid tumor heterogeneity and the tumor microenvironment. The fusion of scFv with ligands enables

Study identifies MD-1 as endogenous agonist for orphan receptor GPRC5B, linking macrophages to adipocyte signaling

One-third of all nonodorant G protein–coupled receptors (GPCRs) in humans are orphans with no known ligands. Deorphanization of these GPCRs