Steroids during acute COVID-19 do not prevent long COVID in children, large RECOVER study finds
By
Kathryn Hirabayashi,
Summary
This study from the RECOVER Initiative evaluated whether steroid use (dexamethasone, prednisone, prednisolone, methylprednisolone) during acute SARS-CoV-2 infection prevents long COVID in children. Using a retrospective cohort design with target trial emulation methodology, researchers analyzed 854,128 children/youth (768,845 outpatients and 85,283 inpatients). After propensity weighting, the study found that steroids did not reduce the overall risk of post-acute sequelae of SARS-CoV-2 (PASC) in either hospitalized or outpatient children, with one exception: a lower risk of gastrointestinal PASC in hospitalized treated patients (HR: 0.58; 95% CI: 0.39–0.85, p = 0.01). The authors conclude that additional studies are needed to confirm the benefit of steroids and other immunomodulators in preventing long COVID in children.
Source
bskySteroids during acute COVID-19 do not prevent long COVID in children, large RECOVER study findsjournals.plos.orgKey quotes
· 4 pulledIn hospitalized patients, there were no significant treatment differences in the development of PASC in the 1−6 months following acute SARS-CoV-2 infection except for a lower risk of gastrointestinal PASC in treated patients (HR: 0.58; [95% CI: 0.39–0.85], p = 0.01).
In outpatients, no treatment differences were observed in the development of PASC subphenotypes.
Steroids administered during acute SARS-CoV-2 infection did not lead to a decreased risk of PASC, with the exception of gastrointestinal presentations.
Additional studies are needed to confirm the benefit of steroids and other immunomodulators in preventing long COVID.
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