Engineered AAVs Bypass Blood-Brain Barrier via Glymphatic System in Mice
Scientists demonstrate a novel AAV delivery strategy using the brain's glymphatic system to target glial cells, potentially enabling future brain-directed gene therapies.
Read the full articleYou might also wanna read
Engineered AAVs Harness Glymphatic System to Reach Brain Targets in Mice
By delivering engineered adeno-associated viruses through the brain's fluid transport network to target glial cells, scientists demonstrated
Study uses brain's glymphatic system to deliver gene therapy across blood-brain barrier
A new study describes a gene therapy strategy that uses the brain's own glymphatic transport system to distribute engineered viral vectors t
news-medical.net·2d ago
Novel Blood-Brain Barrier Modulation Strategy Shows Promise for Alzheimer's Treatment Through Enhanced Amyloid-β Clearance
The blood‒brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially h
nature.com·8mo ago
Non-invasive genetic tracing reveals 'nearest exit' principle in brain protein clearance pathways
Neuronal protein tracing, unlike CSF tracers, reveals that brain clearance follows a “nearest exit” principle through distinct border immune
New platform combines precision gene targeting with brain-wide delivery
The platform overcomes a key obstacle to delivering gene therapies throughout the brain.
Advances in Brain-on-a-Chip and BBB-on-a-Chip Models for Neurodegenerative Disease Research
Brain-on-a-chip is a microphysiologic platform that comprises cultured brain cells to understand brain disease pathogenesis and treatment. T
journals.sagepub.com·16d ago
Comments
Sign in to join the conversation.
No comments yet. Be the first.