Dietary soy promotes gut bacteria that cooperatively induce immune responses and protect against Salmonella in mice
By
Daisuke Takahashi1,8 Send email to [email protected]
Baker's choice. Dense with flavour, light on filler.
Summary
This study demonstrates that dietary soy shapes the gut microbiome in weaning mice by promoting the expansion of two commensal bacterial species, Limosilactobacillus reuteri and Muribaculum intestinale. These bacteria work cooperatively: L. reuteri provides antigens for T follicular helper (Tfh) cell activation, while M. intestinale acts as an adjuvant by promoting IL-1β production. This leads to robust Tfh cell and IgA antibody responses in Peyer's patches, which helps maintain gut microbiota homeostasis and provides protection against Salmonella infection.
Key quotes
· 5 pulledDietary soy elicits a robust Tfh cell and IgA response in Peyer's patches of weaning mice.
L. reuteri provides cognate antigens for Tfh cell activation, while M. intestinale functions as an adjuvant by promoting IL-1β production.
This polyreactive IgA maintains gut microbiota homeostasis and confers protection against Salmonella infection.
Diet impacts gut microbes and, subsequently, host immunity, but our understanding of the mechanisms driving this axis remains incomplete.
Soy feeding promotes the expansion of two principal commensal bacterial species, Limosilactobacillus reuteri and Muribaculum intestinale.
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