Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release
In presynaptic nerve terminals, the endocytic apparatus rapidly restores synaptic vesicles after neurotransmitter release. Many endocytic proteins localize to the periactive zone, a loosely defined…
Read the full articleYou might also wanna read
An intrinsic cytoskeletal oscillator establishes neuronal polarity
Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10755-6 The ARP2/3 complex works together with actomyosin in an oscillatory p
Dual platform spatial transcriptomics reveals parvalbumin interneuron subtype vulnerability in mouse models of Alzheimer’s disease
Dual platform spatial transcriptomics reveals vulnerability of parvalbumin interneurons in Alzheimer's mouse models, focusing on the affecte
Columbia University study links neuron cleanup system to early Alzheimer's tau tangles
Columbia researchers identify a neuron cleanup system that may help trigger Alzheimer’s tau tangles early in disease.
thebrighterside.news·1mo ago
Study reveals how G-protein regulatory network controls GPCR internalization and spatial positioning
G protein–coupled receptors (GPCRs) enable chemical communication between cells and are involved in nearly all essential functions. They tra
pnas.org·22d agoCaspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology
Caspase-4 transgenic mice show cytoplasmic TDP-43 accumulation, crucial for studying ALS. This model solves previous limitations, unlocking
Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice - Nature Aging
A study in Nature Aging identifies a region of the ALS-linked protein TDP-43 and shows that a brain-penetrant small molecule targeting this
Comments
Sign in to join the conversation.
No comments yet. Be the first.