Declining mRNA synthesis capacity drives organismal aging across species
The abundance of mRNA sets a ceiling on a cell’s capacity to produce protein and carry out its functions. Here, we describe a pathological decline in absolute mRNA abundance that occurs in most cell…
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Evolved constraints to human energy transformation force the body–brain system to operate an economy of energy. To survive and thrive, an or

Energy constraint model of human health: How metabolic trade-offs shape aging and disease
Evolved constraints to human energy transformation force the body–brain system to operate an economy of energy. To survive and thrive, an or

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