Single-Cell Transcriptomics Reveals Cellular Heterogeneity in Arterial Aging
By
He Xu
Summary
This review article examines how single-cell RNA sequencing (scRNA-seq) technologies are revealing the cellular heterogeneity underlying arterial aging. It discusses age-related vascular changes including arterial stiffening, reduced elasticity, extracellular matrix remodeling, chronic low-grade inflammation, and accumulation of senescence-associated cell states. The review synthesizes current single-cell transcriptomic studies across species to identify age-associated changes in endothelial cells, smooth muscle cells, and other arterial wall subpopulations.
Source
Twitter / XSingle-Cell Transcriptomics Reveals Cellular Heterogeneity in Arterial Agingonlinelibrary.wiley.comKey quotes
· 3 pulledArterial aging is a major risk factor for cardiovascular disease and is associated with progressive changes in vascular structure and function.
Recent advances in single-cell RNA sequencing (scRNA-seq) have provided new opportunities to resolve the cellular heterogeneity underlying these age-related alterations in the arterial wall.
Transcriptomic profiling studies across species identify age-associated endothelial, smooth muscle, ...
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