Updated Cochrane Review Finds Modest Prostate Cancer Mortality Reduction from PSA Screening, But Overdiagnosis Risks Remain
By
Megan Brooks
Summary
An updated Cochrane review finds that PSA screening probably reduces prostate cancer deaths by about 2 per 1000 men screened, a shift from the group's 2013 conclusion that screening did not significantly lower mortality. However, the modest benefit comes with increased diagnoses of localized cancers that may never become clinically significant, highlighting the ongoing trade-off between potential mortality reduction and overdiagnosis risks.
Source
Twitter / XUpdated Cochrane Review Finds Modest Prostate Cancer Mortality Reduction from PSA Screening, But Overdiagnosis Risks Remainmdsc.peKey quotes
· 3 pulledPSA screening reduces prostate cancer deaths by about 2 per 1000 men screened
The new analysis, based on longer follow-up and additional trial data, suggests that PSA screening reduces prostate cancer deaths
This modest benefit comes at the cost of an increased number of prostate cancer diagnoses, many of which are localized cancers that may never have become clinically significant
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