Long-read sequencing reveals archaic structural variants in Papua New Guinean genomes
By
Evan E. Eichler
Fresh out the oven, still warm. Top of the tray.
Summary
This article presents a genetic study using long-read sequencing to identify archaic-derived structural variants (SVs) in two Papua New Guinean individuals. The research found unique insertions and deletions inherited from Neanderthals and Denisovans, including 11 centromeres potentially introgressed from archaic humans. The study addresses the underrepresentation of Oceanian populations in genetic research and provides a global map of introgressed structural variation and selection in humans.
Key quotes
· 3 pulledBetween 2 and 5% of modern Eurasian genomes are derived from admixture with Neanderthals and Denisovans, with Papua New Guineans bearing the largest fractions.
Oceanian populations remain underrepresented in genetic studies, resulting in questions about the landscape of archaic introgression.
Hsieh et al. used long-read sequencing to identify archaic-derived structural variants in two Papua New Guinean individuals, finding many unique insertions and deletions, as well as 11 centromeres potentially in...
You might also wanna read
The Evolution of DNA Sequencing: From Sanger to Nanopore Technology
This article provides a comprehensive visual guide to DNA sequencing technologies, tracing the evolution from the Human Genome Project's ini
asimov.press·3mo ago
Genome sequencing of hallucinogenic Yunnan bolete reveals unknown compound behind visions
Researchers at the University of Utah have sequenced the genomes of 53 specimens of the Yunnan bolete mushroom, which causes hallucinations
psychedelics.co.uk·13h ago
Genetic Ancestry of an Old Kingdom Egyptian Revealed Through Whole-Genome Sequencing
The article discusses the whole-genome ancestry of an Old Kingdom Egyptian based on DNA sequencing of an adult male excavated at Nuwayrat. T
nature.com·11mo ago
David Reich's Genetics Lab Rewrites Human History Through Ancient DNA Analysis
The article profiles David Reich's ancient genetics lab at Harvard Medical School, which is revolutionizing our understanding of human histo
laphamsquarterly.org·9mo ago
Oxford study reveals ancient genome duplications enabled evolution of complex vertebrate brains
A new Oxford-led study reveals that whole-genome duplication events in early vertebrate evolution provided the genetic raw material for the
ox.ac.uk·1d ago