Basal forebrain PV neurons, not cholinergic neurons, drive sustained attention in mice
By
Shu-Jing Li (李舒婧)1,2 Send email to [email protected]
Summary
This article presents a scientific study on the neural circuits underlying sustained attention in mice. It identifies parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain as key mediators of sustained attention, challenging the traditional focus on cholinergic neurons. The study shows that a long-range inhibitory projection from the basal forebrain disinhibits the cortex to amplify sensory responses, encoding motivational salience and predicting moment-to-moment attentional performance.
Source
bskyBasal forebrain PV neurons, not cholinergic neurons, drive sustained attention in micecell.comKey quotes
· 3 pulledThe basal forebrain is integral to attention by modulating cortical activity, but recent evidence challenges the role of its signature cholinergic neurons in sustaining attention.
Here, we demonstrate that another cortex-projecting basal forebrain cell type, parvalbumin-expressing (BF-PV) inhibitory neurons, mediates sustained attention.
This circuit encodes motivational salience and predicts moment-to-moment attentional performance, providing a mechanism for the real-time control of sustained attention.
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