Using CRISPR-Cas9 for Trisomic Rescue in Down Syndrome Cells
By
MattSayar
Master baker tier. Every paragraph earns its place on the tray.
Summary
The study demonstrates the use of CRISPR-Cas9 to achieve trisomy rescue by eliminating the target chromosome from human trisomy 21 cells.
Key quotes
· 3 pulledHuman trisomy 21, responsible for Down syndrome, is the most prevalent genetic cause of cognitive impairment.
The present study demonstrates that allele-specific multiple chromosome cleavage by clustered regularly interspaced palindromic repeats Cas9 can achieve trisomy rescue.
Research directed toward eliminating supernumerary chromosomes from trisomic cells is limited.
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