Study Links Long-Term Melatonin Use to Increased Heart Failure and Mortality Risks
By
pogue
A bagel you'd recommend to a friend without hedging.
Summary
A preliminary study presented at the American Heart Association's Scientific Sessions 2025 found that long-term melatonin use (one year or longer) for chronic insomnia is associated with significantly increased risks of heart failure, hospitalization for heart failure, and all-cause mortality. Chronic melatonin users were almost twice as likely to die and 3.5 times more likely to be hospitalized for heart failure compared to non-users. The research challenges the widespread perception of melatonin as harmless and urges caution with extended use of the popular sleep supplement.
Key quotes
· 4 pulledadults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement
chronic users were almost twice as likely to die and 3.5 times more likely to be hospitalized for heart failure
Though melatonin is widely regarded as harmless, experts now urge caution with extended use
Long-term melatonin use for sleep problems may come with unexpected heart dangers
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