Study Challenges Decades-Old View That DNA Is Locked Away When Wrapped Around Nucleosomes

Summary

A new study from Gladstone Institutes and the Arc Institute challenges the long-held belief that DNA wrapped around nucleosomes is locked away and inaccessible. The prevailing view held that only unwrapped DNA could be active, but this research reveals that DNA isn't as tightly sealed as previously thought, with implications for understanding how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.