MAIT cell evasion is critical for Listeria monocytogenes pathogenesis, study finds
By
Daniel A. Portnoy
Fresh out the oven, still warm. Top of the tray.
Summary
This article examines how the bacterial pathogen Listeria monocytogenes evades MAIT cells (mucosal-associated invariant T cells), which are innate-like immune cells that recognize microbial riboflavin precursors via MR1 molecules. The research demonstrates that MAIT cell avoidance is a critical factor in Listeria pathogenesis, highlighting the evolutionary importance of these highly conserved immune cells found across mammals. The study explores the mechanisms by which Listeria monocytogenes subverts MAIT cell-mediated immunity to establish infection.
Key quotes
· 3 pulledMucosal-associated invariant T (MAIT) cells are innate-like T cells that primarily recognize a conserved microbial-derived riboflavin precursor presented by monomorphic major histocompatibility complex (MHC) class I-related (MR1) molecules
The MAIT cell semi-invariant T cell receptor (TCR) alpha-chain and MR1 are highly conserved among nearly all mammals, suggesting strong evolutionary pressure for their maintenance
Upon activation, MAIT cells produce potent antimic...
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