Paediatric autoimmunity: Understanding shared vulnerability and disease co-occurrence in children
By
Kirsten Mindena,b Send email to [email protected] ∙ Tilmann Kallinicha,c,d
Master baker tier. Every paragraph earns its place on the tray.
Summary
This article discusses paediatric autoimmunity, explaining how autoimmune diseases arise from a breakdown of adaptive immune tolerance. It references a large UK population-based study showing autoimmune diseases affect about 10% of the population, with higher prevalence in females and most diagnoses after age 50. The article notes that while several autoimmune conditions appear in childhood and adolescence, the temporal sequence and co-occurrence across the spectrum of paediatric autoimmunity remain poorly understood.
Key quotes
· 3 pulledAutoimmunity arises from a breakdown of adaptive immune tolerance, whereby impaired recognition of self-antigens triggers inappropriate immune responses leading to tissue injury and organ dysfunction.
A large UK population-based study with no age restriction estimated that autoimmune diseases affect approximately 10% of the population, with rising incidence, higher prevalence in females, and most diagnoses occurring after age 50 years.
Although several autoimmune conditions manifest in childhood and adolescence, the temporal sequence and co-occurrence across the broader spectrum of paediatric autoimmunity remain poorly characterised.
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