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Largest Alzheimer's genetics study identifies 127 gene locations, including 48 new targets for drug development

By

Chris Simms

1d ago· 5 min readenNews

Summary

The largest genetic study of Alzheimer's disease to date has identified 127 gene locations associated with the condition, including 48 newly discovered ones. The research highlights potential drug targets and specific cell types linked to higher genetic risk. Alzheimer's is highly heritable, and this study significantly expands the known genetic landscape of the disease, offering new avenues for therapeutic development.

Key quotes

· 3 pulled
It's an exciting time for Alzheimer's genetics
The biggest genetic study of Alzheimer's disease so far has identified 127 gene locations that are associated with the condition, of which 48 are new
The study also pinpoints several genes that could be prioritised as drug targets and cell types linked to a higher genetic risk of the condition
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Almost 50 more genes have been flagged as being linked to Alzheimer’s, along with changes in activity in crucial cells that disappear as dementia progresses

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