Alzheimer's Disease Disrupts Circadian Rhythms in Brain Cells Responsible for Amyloid Clearance
By
gmays
Pulled from the oven just right. Trustworthy, fact-dense, deeply satisfying.
Summary
A mouse study from Washington University School of Medicine reveals that Alzheimer's disease disrupts the circadian rhythms of brain cells responsible for clearing amyloid plaques. Published in Nature Neuroscience, the research shows that amyloid accumulations in Alzheimer's-affected brains throw off the daily rhythms of hundreds of genes in microglia and astrocytes, specialized cells involved in amyloid removal. These disruptions differ from normal aging effects and may contribute to the sleep disturbances and cognitive decline characteristic of Alzheimer's disease.
Key quotes
· 5 pulledAlzheimer's disease is notorious for scrambling patients' daily rhythms. Restless nights with little sleep and daytime drowsiness are common symptoms.
Mouse study shows how disease reprograms genes in specialized cells involved in amyloid removal.
Amyloid accumulations in the brain — which are characteristic of Alzheimer's disease — threw off the daily rhythms of hundreds of genes in brain cells known as microglia and astrocytes.
These disruptions were different from what aging alone caused.
The findings suggest that Alzheimer's disease fundamentally alters the biological clocks of brain cells responsible for clearing toxic proteins.
You might also wanna read
Japanese researchers develop vitamin K-like compounds that may help convert brain cells into neurons
Japanese researchers have developed a new family of vitamin K-like molecules that may help immature brain cells transition into neurons. Whi
zmescience.com·1d ago
Gladstone Scientists Develop New Tool to Map Brain Waste Clearance Mechanisms
Gladstone scientists have developed a new tool to trace how the brain clears waste, revealing surprising new biology about the brain's self-
gladstone.org·2d ago
Texas A&M researchers develop nasal spray that reverses brain aging in study
Researchers at Texas A&M University have developed a nasal spray that appears to reverse brain aging by reducing inflammation and restoring
Northwestern study identifies schizophrenia biomarker and potential drug candidate for cognitive symptoms
A Northwestern University study in humans and mice has identified a novel biomarker for schizophrenia that could also serve as a drug candid
news.northwestern.edu·2mo ago
Salk Institute Study Finds Cannabinoids May Help Remove Alzheimer's-Related Proteins from Brain Cells
Salk Institute researchers have found preliminary evidence that THC and other cannabinoids can promote the cellular removal of amyloid beta
salk.edu·2mo ago
Oxford Neuroscientists Discover Connection Between Tinnitus and Sleep in the Brain
Neuroscientists at the University of Oxford have discovered a previously overlooked connection between tinnitus and sleep in the brain. Thei
sciencealert.com·2mo ago