Single-cell analysis reveals sex-based differences in immune system gene expression
By
Seyhan Yazar1,2,3 Send email to [email protected]
Slow-proofed and worth the wait. Worth its weight in flour.
Summary
This study examines sex-based differences in the immune system at single-cell resolution. Researchers found that female-biased differentially expressed genes (DEGs) in immune cells are involved in TNF-α signaling, while male DEGs are enriched for ribosomal-related functions. The research by Yazar et al. used sex-differential expression and sex-stratified eQTLs to identify sex-biased genes and pathways linked to autoimmune diseases, suggesting that baseline sexual dimorphism provides a molecular foundation for sex-specific disease susceptibility.
Key quotes
· 4 pulledSex has a key role in disease susceptibility (in particular, autoimmunity).
Sex differences in the immune system originate from genes and their interactions with both intrinsic and extrinsic factors.
Female-biased sex-differentially expressed genes (sex-DEGs) in multiple immune cells were involved in tumor necrosis factor alpha (TNF-α) signaling, whereas male DEGs were enriched for ribosomal-related
They identified sex-biased genes and pathways, including those previously linked to autoimmune diseases, suggesting that baseline sexual dimorphism in the immune system provides a molecular foundation for sex-specific disease susceptibility.
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