Study Shows Theta Burst Stimulation Can Enhance Antidepressant Placebo Effects via Default Mode Network Activation
By
Ian Snyder, BS1; Kevin Handoko, BS1; Alyssa Neppach, BS2 et al
A respectable bake. You'd come back tomorrow for another.
Summary
This randomized clinical trial investigated whether intermittent theta burst stimulation (iTBS) over the dorsomedial prefrontal cortex can harness antidepressant placebo effects by potentiating default mode network (DMN) activity. In 50 adults with depressive symptoms not taking psychotropic medication, iTBS significantly increased DMN activation during antidepressant expectancy cues compared to continuous TBS, following a monotonic pattern. Greater DMN activation under iTBS was associated with larger expectancy-driven mood improvements, suggesting neuromodulation may enhance placebo-based antidepressant responses.
Key quotes
· 3 pulledIntermittent theta burst stimulation (iTBS) significantly increased DMN activation during antidepressant expectancy cues compared with continuous TBS, following a monotonic pattern across conditions.
Greater activation under iTBS was associated with larger expectancy-driven mood improvements.
This randomized clinical trial investigates if neuromodulation can harness antidepressant placebo effects by potentiating default mode network activity via theta burst stimulation over the dorsomedial prefrontal cortex (PFC).
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