Flagellin in biotechnology: biosensors, nanomaterials, and nanorobots beyond bacterial motility
By
Jacob Scadden Send email to [email protected]
A baker's-dozen of insight crammed into one ring.
Summary
This review article discusses recent advances in using flagellin (the bacterial flagellar filament protein) for biotechnology applications beyond its natural role in bacterial motility. Flagellin's structure allows for outer domain customization, making it useful for generating biosensors, forming nanomaterials, attaching cells to surfaces, and conferring motility to nanorobots. The article highlights how modified flagellin (both as monomers and polymeric filaments) offers a cost-effective solution to limitations of traditional methods in medical and nanobiotechnology.
Key quotes
· 4 pulledRoughly 30,000 copies of flagellin self-polymerize into the bacterial flagellar filament, an extracellular appendage responsible for the propulsion of bacteria through the generation of thrust via rotation.
The structure of flagellin allows for outer domain customization, which has been the target of numerous studies for applications in biotechnology.
Flagellin is well characterized and provides a promising and cost-effective answer to some of the current limitations of traditional methods.
Modified flagellin, both as monomers and in polymeric filaments, has been used in the generation of biosensors, in the formation of nanomaterials, in the attachment of cells to surfaces of interest, and in conferring motility to nanorobots.
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