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Washington University researchers develop rapid method to produce enzymes that break down misfolded proteins in ALS and Parkinson's

By

Leah Shaffer

5d ago· 4 min readenNews

Summary

Researchers at Washington University in St. Louis, led by associate professor Meredith Jackrel, have developed a new high-throughput method to rapidly produce and screen "disaggregase" enzymes capable of breaking down misfolded proteins associated with neurodegenerative diseases like ALS and Parkinson's disease. This advancement overcomes previous slow and tedious methods for identifying these promising therapeutic enzymes.

Key quotes

· 2 pulled
Disaggregases have a lot of promise, but previous methods for producing and identifying them were extremely slow and tedious
Our new method is a significant step forward
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Researchers at Washington University in St. Louis devised a new high-tech method to generate an enzyme that can break down the misfolded proteins that cause neurodegenerative disease.

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