Tissue-specific regulation of IL-17 signaling in immunobiology
By
Sarah L. Gaffen
Crackling crust, pillowy middle. The kind of bagel that earns a second cup of coffee.
Summary
This article reviews recent advances in understanding the cell- and tissue-specific activities of IL-17 family cytokines, which are central regulators of tissue immunity. It covers the signaling pathways involved in IL-17-mediated immunobiology, including how IL-17 signaling is regulated differently across various tissues. The review references key studies on IL-17, including its discovery as a cytokine encoded by Herpesvirus saimiri and its role in mucosal immunity and gut barrier function via type 17 immunity.
Key quotes
· 3 pulledIL-17 family cytokines are central regulators of tissue immunity.
Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Mucosal fungi promote gut barrier function and social behavior via type 17 immunity.
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