Cohort Study Evaluates Age at Onset and Family History as Predictors for Genetic Testing in Parkinson Disease
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Summary
This cohort study evaluates the association between age at onset (AAO) and family history in Parkinson disease patients who carry pathogenic genetic variants. The study analyzes data from four major datasets (GP2, MDSGene, PD GENEration, and ROPAD) to determine optimal AAO thresholds for genetic testing. The findings suggest that AAO alone or combined with family history can help predict genetic forms of Parkinson disease, with performance curves showing varying sensitivity across different age thresholds. The research aims to improve genetic testing criteria and counseling for Parkinson disease patients.
Key quotes
· 3 pulledFigure 1 shows performance curves for predicting any genetic form of Parkinson disease using AAO alone or in combination with positive family history across 4 datasets.
The study evaluates the association between age at onset and family history of Parkinson disease in patients who carry pathogenic variants.
Area under the receiver operating characteristic curve (ROC) for predicting any genetic form of Parkinson disease using AAO alone or in combination with positive family history.
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